The 61-year-old is to quit at the end of the season, along with his technical staff, after two years in charge
Lille have announced that head coach Rene Girard will leave the club at the end of the season by mutual consent.
Girard has been in charge at Stade Pierre-Mauroy since 2013 and is joined by assistants Gerard Bernadet and Nicolas Girard in making an exit.
The club sit eighth in Ligue 1 with one match left to play and, while not mathematically impossible, any improvement on that appears unlikely due to an inferior goal difference compared to seventh-placed Montpellier.
Girard will make his final bow as Lille boss at Metz on Saturday, with Cote d’Ivoire coach Herve Renard among the favourites to succeed the 61-year-old.
“President Michel Seydoux and the club would like to acknowledge the human values and qualities of Rene Girard, with whom our relationship has always been sincere and respectful,” read a statement on the club’s official website.
“LOSC and its directors wish him the very best of success in his professional endeavours in the future.”
Lille have promised the announcement of a new coach by the end of the month.